I don't understand exactly how rune of chaos works... Isn't it single target? Why would I use a single target spell that gives only 50% of my damage potential? That seems more like a debuff to me.
And yeah, I'm aiming for PvE, since Scythe Warlock's role in PvP is usurped by other classes.
I don't want to take away Kinetic Shield but if my End is increased enough I guess it shouldn't be a problem. Same thing for Pure Mind since I'm losing all my Luck points and crit chance +30% would no longer matter. All these changes would make combat slower overall imo since my Int and Crt are majorly decreasing and being replaced by Agi (supposedly useless) and End (which makes no sense to max if I'm not a tank, but whatevs).
Lastly, then: Wave of Strength vs Rune of Madness.
[According to your suggests, Int = 38, End = 100, Agi = 100, Crt = 1.]